人才简介


李孝训 教授
作者:  来源:  发布时间:2018年10月24日 10:41  浏览次数:

 

李孝训,皇冠体育在线教授,药物化学专业博士生导师。2017年入选山东大学齐鲁青年学者。近五年,已在J. Am. Chem. Soc.Angew. Chem. Int. Ed.Chem. Sci. 等国际著名刊物上发表论文二十余篇,已获得授权美国专利2项。

一、主要研究方向

  方向1. 基于靶点结构的药物活性小分子的设计、合成及生物活性研究;

方向2. 具有重要生理活性的复杂天然产物的全合成及构效关系研究。 

二、标志性成果

(一)承担重大课题

1.山东大学齐鲁青年学者启动基金

(二)主编教材及著作

1.Xiaoxun Li, Weiping Tang. Metal-catalyzed [5+1], [5+2] and [5+2+1] cycloadditions. An invited chapter in Science of Synthesis: Metal-Catalyzed Cyclization Reactions. Shengming Ma, Shuanhu Gao. 2016, Thieme, ISBN: 9783131998118.

(三)获奖情况

1.山东大学齐鲁青年学者2017

2.国家优秀自费留学生奖学金,2014

(四) 代表性学术论文 (限10篇)

1.Barry M. Trost*, Xiaoxun Li. “Palladium Catalyzed Asymmetric Allylic Alkylations via C-H Activation of N-allyl Imines and Glycinates” Chem. Sci. 2017, 8, 6815-6821.  

2.Xiaoxun Li, Hui Li, Wangze Song, Po-Sen Tseng, Lingyan Liu, Ilia A. Guzei, Weiping Tang* “Divergent Reactivity of Rhodium (I)  Carbenes Derived from Indole Annulations” Angew. Chem. Int. Ed. 2015, 54, 12905-12908.

3.Xiaoxun Li, Wangze Song, and Weiping Tang* “Rhodium-catalyzed Tandem Annulation and  [5+1] Cycloaddition: 3-Hydroxy -1,4-enyne as the 5-Carbon component” J. Am. Chem. Soc., 2013, 135, 16797-16800.

4.Xiaoxun Li, Min Zhang, Dongxu Shu, Patrick J. Robichaux, Suyu Huang, and Weiping Tang* “Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings by 1,5-C-C Bond Migration” Angew. Chem. Int. Ed., 2011, 50, 10421-10424.

5.Xiaoxun Li, Haibo Xie, Xiaoning Fu, Jitian Liu, Haoyuan Wang, Baomin Xi, Xiufang Xu, Peng Liu, Weiping Tang* “Rhodium(I)-catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles” Chem. Eur. J. 2016, 22, 10410-10414.

6.Xiaoxun Li, Wangze Song, Xiaona Ke, Xiufang Xu, Peng Liu, K. N. Houk, Xian-liang Zhao, Weiping Tang* “Rhodium-catalyzed Intramolecular [5+2] Cycloaddition of Inverted 3-Acyloxy-1,4-enyne and Alkyne: Experimental and Theoretical Studies” Chem. Eur. J. 2016, 22,7079 –7083.

7.Xiaoxun Li,  Suyu Huang,  Casi M. Schienebeck, Dongxu Shu, and Weiping Tang* “Rhodium-Catalyzed Carbonylation of 3-Acyloxy-1,4-enynes for the Synthesis of Cyclopentenones” Org. Lett., 2012, 14, 1584-1587.

8.Xiaoxun Li, Yunfei Du*, Zhidan Liang , Xiangke Li , Yan Pan and Kang Zhao* “Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions” Org. Lett., 2009, 11, 2643-2646.

9.Xing-zhong Shu, Xiaoxun Li, Dongxu Shu, Suyu Huang, Casi M. Schienebeck, Xin Zhou, Patrick J. Robichaux, and Weiping Tang* “Rhodium-catalyzed Intra- and Intermolecular [5+2] Cycloaddition of 3-Acyloxy-1,4-enyne and Alkyne with Concomitant 1,2-Acyloxy Migration” J. Am. Chem. Soc., 2012, 134, 5211-5221.

10.Dongxu Shu, Xiaoxun Li, Min Zhang, Patrick J. Robichaux, and Weiping Tang* “Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition” Angew. Chem. Int. Ed. 2011, 50, 1346-1349.

 
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 人才简介

李孝训 教授
发布日期:2018-10-24  浏览次数:

 

李孝训,皇冠体育在线教授,药物化学专业博士生导师。2017年入选山东大学齐鲁青年学者。近五年,已在J. Am. Chem. Soc.Angew. Chem. Int. Ed.Chem. Sci. 等国际著名刊物上发表论文二十余篇,已获得授权美国专利2项。

一、主要研究方向

  方向1. 基于靶点结构的药物活性小分子的设计、合成及生物活性研究;

方向2. 具有重要生理活性的复杂天然产物的全合成及构效关系研究。 

二、标志性成果

(一)承担重大课题

1.山东大学齐鲁青年学者启动基金

(二)主编教材及著作

1.Xiaoxun Li, Weiping Tang. Metal-catalyzed [5+1], [5+2] and [5+2+1] cycloadditions. An invited chapter in Science of Synthesis: Metal-Catalyzed Cyclization Reactions. Shengming Ma, Shuanhu Gao. 2016, Thieme, ISBN: 9783131998118.

(三)获奖情况

1.山东大学齐鲁青年学者2017

2.国家优秀自费留学生奖学金,2014

(四) 代表性学术论文 (限10篇)

1.Barry M. Trost*, Xiaoxun Li. “Palladium Catalyzed Asymmetric Allylic Alkylations via C-H Activation of N-allyl Imines and Glycinates” Chem. Sci. 2017, 8, 6815-6821.  

2.Xiaoxun Li, Hui Li, Wangze Song, Po-Sen Tseng, Lingyan Liu, Ilia A. Guzei, Weiping Tang* “Divergent Reactivity of Rhodium (I)  Carbenes Derived from Indole Annulations” Angew. Chem. Int. Ed. 2015, 54, 12905-12908.

3.Xiaoxun Li, Wangze Song, and Weiping Tang* “Rhodium-catalyzed Tandem Annulation and  [5+1] Cycloaddition: 3-Hydroxy -1,4-enyne as the 5-Carbon component” J. Am. Chem. Soc., 2013, 135, 16797-16800.

4.Xiaoxun Li, Min Zhang, Dongxu Shu, Patrick J. Robichaux, Suyu Huang, and Weiping Tang* “Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings by 1,5-C-C Bond Migration” Angew. Chem. Int. Ed., 2011, 50, 10421-10424.

5.Xiaoxun Li, Haibo Xie, Xiaoning Fu, Jitian Liu, Haoyuan Wang, Baomin Xi, Xiufang Xu, Peng Liu, Weiping Tang* “Rhodium(I)-catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles” Chem. Eur. J. 2016, 22, 10410-10414.

6.Xiaoxun Li, Wangze Song, Xiaona Ke, Xiufang Xu, Peng Liu, K. N. Houk, Xian-liang Zhao, Weiping Tang* “Rhodium-catalyzed Intramolecular [5+2] Cycloaddition of Inverted 3-Acyloxy-1,4-enyne and Alkyne: Experimental and Theoretical Studies” Chem. Eur. J. 2016, 22,7079 –7083.

7.Xiaoxun Li,  Suyu Huang,  Casi M. Schienebeck, Dongxu Shu, and Weiping Tang* “Rhodium-Catalyzed Carbonylation of 3-Acyloxy-1,4-enynes for the Synthesis of Cyclopentenones” Org. Lett., 2012, 14, 1584-1587.

8.Xiaoxun Li, Yunfei Du*, Zhidan Liang , Xiangke Li , Yan Pan and Kang Zhao* “Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions” Org. Lett., 2009, 11, 2643-2646.

9.Xing-zhong Shu, Xiaoxun Li, Dongxu Shu, Suyu Huang, Casi M. Schienebeck, Xin Zhou, Patrick J. Robichaux, and Weiping Tang* “Rhodium-catalyzed Intra- and Intermolecular [5+2] Cycloaddition of 3-Acyloxy-1,4-enyne and Alkyne with Concomitant 1,2-Acyloxy Migration” J. Am. Chem. Soc., 2012, 134, 5211-5221.

10.Dongxu Shu, Xiaoxun Li, Min Zhang, Patrick J. Robichaux, and Weiping Tang* “Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition” Angew. Chem. Int. Ed. 2011, 50, 1346-1349.

 
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